wilate Dosing Information for the Treatment of VWD
wilate has low recommended loading and maintenance dosing for all VWD types 1*
Minor Hemorrhages
| Loading dosage (IU VWF:RCo/kg BW) |
Maintenance dosage (IU VWF:RCo/kg BW) |
Therapeutic goal |
|---|---|---|
| 20-40 IU/kg | 20-30 IU/kg every 12-24 hours* |
VWF:RCo and FVIII activity trough levels of >30% |
Major Hemorrhages
| Loading dosage (IU VWF:RCo/kg BW) |
Maintenance dosage (IU VWF:RCo/kg BW) |
Therapeutic goal |
|---|---|---|
| 40-60 IU/kg | 20-40 IU/kg every 12-24 hours* |
VWF:RCo and FVIII activity trough levels of >50% |
| RCo=ristocetin cofactor; BW=bodyweight. *This may need to be continued for up to 3 days for minor hemorrhages and 5 to 7 days for major hemorrhages. *Based on the Recommended Dosing Guide for wilate. See Dosage and Administration, section 2.1 of full Prescribing Information. |
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Humate-P® is a VWF/FVIII complex for the treatment of VWD with recommended loading dose ranges that are typically higher than wilate, and recommended maintenance dosing intervals that are typically shorter.
Humate-P® VWF:RCo dosing recommendations for the treatment of bleeding episodes by VWD type2
Type 1 VWD – Mild (baseline VWF:RCo activity typically>30%)
| Severity of Hemorrhage | Dosage (IU VWF:RCo/kg BW) |
|---|---|
| Minor (eg, epistaxis, oral bleeding, heavy menstrual bleeding) |
Typically treatable with desmopressin. |
| Minor (when desmopressin is known or suspected to be inadequate) Major (eg, severe or refractory epistaxis, GI bleeding, CNS trauma, traumatic hemorrhage) |
Loading dose 40-60 IU/kg. Then 40-50 IU/kg every 8-12 hours for 3 days to keep the trough level of VWF:RCo>50%.Then 40-50 IU/kg daily for up to 7 days. |
Type 1 VWD – Moderate or severe (baseline VWF:RCo activity typically<30%)
| Severity of Hemorrhage | Dosage (IU VWF:RCo/kg BW) |
|---|---|
| Minor (eg, epistaxis, oral bleeding, menorrhagia) |
40-50 IU/kg (1 or 2 doses) |
| Major (eg, severe or refractory epistaxis, GI bleeding, CNS trauma, hearmathrosis, traumatic hemorrhage) |
Loading dose 50-75 IU/kg Then 40-60 IU/kg every 8-12 hours for 3 days to keep the trough level of VWF:RCo>50%Then 40-60 IU/kg daily for up to 7 days. |
Type 2 VWD (all variants) and Type 3 VWD
| Severity of Hemorrhage | Dosage (IU VWF:RCo/kg BW) |
|---|---|
| Minor (clinical indications above) |
40-50 IU/kg (1 or 2 doses) |
| Major (clinical indications above) |
Loading dose 60-80 IU/kg. Then 40-50 IU/kg every 8-12 hours for 3 days to keep the trough level of VWF:RCo>50%. Then 40-60 IU/kg daily for up to 7 days. |
| GI=gastrointestinal; CNS=central nervous system
*Presentation of Humate-P® dosing information is not intended to claim or imply equivalence to wilate in efficacy, safety, or other conditions of use. *For major bleeds in all types of VWD where repeated dosing is required, monitor and maintain the patient’s FVIII level according to the guidelines for hemophilia A therapy. Humate-P® is manufactured by and is a registered trademark of CSL Behring. |
|
| Vial Sizes |
|---|
| 500 IU VWF:RCo and 500 IU FVIII activities in 5 ml |
| 1000 IU VWF:RCo and 1000 IU FVIII activities in 10 ml |
- Store wilate up to 36 months in a refrigerator at +2°C to +8°C (36°F to 46°F) protected from light from the date of manufacture
- Within this period, wilate may be stored up to 6 months at room temperature (maximum of +25°C or 77°F). Once stored at room temperature, the product must not be returned to the refrigerator.
References
- wilate Full Prescribing Information. Paramus, NJ: Octapharma; rev December 2023.
- Humate-P® Full Prescribing Information. Kankakee, IL: CSL Behring; September 2016.